Endocrine Abstracts

Introduction: β-cell function declines progressively in patients with type 2 diabetes (T2D). the fasting C-peptide/glucose ratio (Cp/G) is used for its evaluation. The GLP1 receptor agonist liraglutide improves glucose and weight control, presumably due to improvement of β-cell function and/or mass. This study evaluates the effect of a 6-months’ treatment with liraglutide in β-cell function, measured by Cp/G, in patients with obesity and T2D.<p class="a...

Several papers show that maternal malnutrition can affect the reproductive capability of the offspring. Leptin is an important regulator of the reproductive system, however little is known about its role in the epididymis. The goal of this study was to evaluate whether the maternal malnutrition during lactation can alter the expression of leptin and its receptors in the epididymis of rats. Six rat dams were randomly assigned to the control group (C), with free access to a stan...

Background: Lithium salts have been widely known to induce thyroid dysfunction, however, parathyroid dysfunction due to lithium use is uncommonly encountered. Hypercalcemia is a relatively common consequence of lithium therapy presenting with nonspecific symptoms that may be overlooked. Although cerebral infarction may be an independent event from psychiatric disorders, it can also be a rare complication that must be recognized particularly in patients on lithium therapy.<...

Introduction: Osteoporosis is a frequent complication associated with primary hyperparathyroidism (PHPT), and surgery is the most effective treatment once established. However, many patients are not candidates for it, and different medical options have been investigated. We aimed to assess the efficacy of denosumab (DMAB) in increasing bone mineral density (BMD) and preventing PHPT-related complications.Methods: Case-control study defining cases (Group 1...

Background: Klinefelter syndrome is the most common sex chromosome abnormality causing primary hypogonadism and affects approximately 1 to 2.5 per 1000 males. However, other rarer sex chromosomal abnormalities have been associated to testicular dysfunction.Clinical Case: A thirteen-year-old male was referenced to Pediatric consultation due to obesity starting around age four. Perinatal background: maternal gestational diabetes controlled with diet and 10...

Introduction: Increased insulin-like growth factor 1 (IGF-1) levels in patients with acromegaly are associated with clinical and radiological osteoarthritis (OA). We aimed to elucidate whether serum IGF-1 levels differ in patients with primary OA as compared to healthy controls and whether genetic variants known to affect serum IGF-1 levels are also associated with primary OA.Methods: Patients from the GARP study with familial generalized OA (n=...

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL ...

The hormone leptin is required for the energy balance regulation. However, leptin also controls many other biological functions. Among these actions, some authors suggest that leptin exhibits neurotrophic effects in early life and plays a key role in the development of neurocircuitries that regulate energy metabolism. However, the precise role of leptin during development is still unclear. Thus, our study had the objective to investigate the consequences of the absence of lept...

Introduction: Radiotherapy (RT) has been proven to be effective in controlling hormone production and tumor growth in pituitary adenomas (PA). Still, RT adverse effects had turned it an unattractive choice of treatment. The aim of this study was to evaluate the efficacy and safety of RT for patients with PA.Methods: We conducted a retrospective study of patients treated in our center, a central hospital, since 1998. Thirty-three patients were included, 6...

Introduction: Guidelines suggest that serum basal (nonstimulated) thyroblobulin (bTg) with sensitive assays (Functional Sensitivity-FS- below 0.1 or 0.2 ng/ml) could substitute the measurement of serum Tg levels after TSH stimulation during the follow-up of patients with differentiated thyroid cancer (DTC) when basal results fall below the FS.Objective: A sensitive assay for Tg was incorporate in our center (Chemiluminiscent Tg Access; Beckam Coulter; Br...